to the bacterial growth [Langridge, et al., 2009; Zomer, et al.,

ng, et al., 2017]. This kind of responsive gene discovery study is

based on a single-condition experiment. If a biology experiment

sed of two conditions, a condition-wise comparison process can

genes with different activities across two conditions. In this

the other approach is employed to discover the responsive genes,

he gene expression pattern discovery [Tusher, et al., 2001; Smyth,

agoyen and Pazos, 2010; Minguez and Dopazo, 2011; Chagoyen,

17; Miller, et al., 2019; Tsuda, et al., 2019].

peptide function discovery problem

g or discovering the protein function within a protein sequence

one of the most researched subjects in biology. Proteins as

lecules have a variety of roles in cells. Metabolism relies on the

l proteins for enzymatic function, working as the energy carriers

s the hormones for chemical reactions in the cells. The protein

are researched mainly in two ways, i.e., the crystal structural

and the primary structure analysis. The crystallising experiment

echnology to investigate the protein structures. For instance, the

d segments of a protein can be discovered using the 3D

ing experiment [Yang, et al., 2005]. The molecular structures of

S2 subunits of SRAS were examined using the crystallising

e [Spiga, et al., 2003]. The study examined the shape and surface

drophobicity in association with the known functional proteins so

leavage pattern between the S1 and S2 subunits can be thoroughly

d. Another recent crystal structure study has examined the

of non-structural protein nine (NSP9) of SARS-CoV-2, which

ate viral replication, the role of promoting virulence as well as

of replicating viral genomic RNAs. Through the use of the

ing technology, it has been found that NSP9 of SARS-CoV-2 is

ructurally conserved [Little, et al., 2020].

ther mainstream of protein function discovery is to research the

rimary structures, i.e., the protein sequences. The pattern of